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Describe the Structure and Functions of Microtubules – Why Can Drugs That Interfere With Microtubule Assembly Be Used as Cancer Therapy?

Microtubules form as a highly organised network of polarised tube filaments from a protein called tubulin. Its regulation is needed for processes such as mitosis, cell migration, cell signalling and cell trafficking. The microtubules themselves are regulated by several kinases and phosphatases via signalling cascades, and concomitantly by interactions with actin cytoskeleton and adhesion sites. […]